Article

Mitochondrial genome instability disrupts brown adipose tissue through pseudohypoxia-iron-NAD⁺ axis

2026-08-31

Abstract excerpt

Brown adipose tissue (BAT) is a mitochondria-rich thermogenic organ whose function depends on high oxidative capacity, yet how primary mitochondrial dysfunction remodels BAT identity and metabolism remains poorly defined. Using the Deletor mouse model of progressive mtDNA deletion disease, we identify a pseudohypoxiairon-NAD+ axis as a central organiser of BAT pathology. Deletor BAT underwent profound structural,...

Identifiers and source

Literature Corpus work: d91a66b2-7787-5249-a58b-13b7629ff863
DOI: 10.64898/2026.08.28.747463

Open publication

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