Article

An inherited mtDNA mutation remodels inflammatory cytokine responses in macrophages and <i>in vivo</i>

2025-01-05

Abstract excerpt

Impaired mitochondrial bioenergetics in macrophages can drive hyperinflammatory cytokine responses 1–6 , but whether this may also be caused by inherited mtDNA mutations is unknown. Here, we address this question using a multi-omic approach that integrates super-resolution imaging and metabolic analyses to profile macrophages from a mouse model of mitochondrial disease arising from a heteroplasmic mutation (m.501...

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Literature Corpus work: af61e650-356f-5e4f-ae28-77aea5ddc5e2
DOI: 10.1101/2025.01.05.631298

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