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Article

Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress.

Proceedings of the National Academy of Sciences of the United States of America - 1 Dec 2015

Picard Martin, McManus Meagan J, Gray Jason D, Nasca Carla, Moffat Cynthia, Kopinski Piotr K, Seifert Erin L, McEwen Bruce S, Wallace Douglas C

Abstract excerpt

The experience of psychological stress triggers neuroendocrine, inflammatory, metabolic, and transcriptional perturbations that ultimately predispose to disease. However, the subcellular determinants of this integrated, multisystemic stress response have not been defined. Central to stress adaptation is cellular energetics, involving mitochondrial energy production and oxidative stress. We therefore hypothesized...

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Identifiers

PMID: 26627253
DOI: 10.1073/pnas.1515733112
PMCID: PMC4672794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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