Article

Mitochondrial dysfunction reshapes methyl-group allocation in skeletal muscle

2026-08-24

Abstract excerpt

Mitochondria are central metabolic organelles with functions extending beyond energy production to anabolic and folate-mediated one-carbon (1C) metabolism. One-carbon metabolism supports methylation reactions that modify diverse targets including metabolites, nucleic acids, and chromatin, and has emerged as a contributor to mitochondrial disease-related stress responses. Here, we report tissue-specific remodeling...

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Literature Corpus work: 519026dd-afac-5198-a789-a0327c895dea
DOI: 10.64898/2026.08.23.746543

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