Article

Murine metabolic HFpEF is associated with mitochondrial substrate inflexibility and S-nitrosylation remodeling

2026-07-13

Abstract excerpt

Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous condition with incompletely defined myocardial mechanisms. Here, using a two-hit murine model of cardiometabolic HFpEF induced by high-fat diet and endothelial nitric oxide synthase inhibition, we define a mitochondrial metabolic phenotype characterized by substrate inflexibility, redox stress, and S-nitrosylation remodeling. While global pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 20512ede-d274-567f-909d-2299e77621fb
DOI: 10.64898/2026.07.11.737886

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Murine metabolic HFpEF is associated with mitochondrial substrate inflexibility and S-nitrosylation remodelingDOI 10.64898/2026.07.11.737886Read

Metabolic inflexibility across heart failure phenotypes: mechanisms and type-specific therapeutic implications.Semantic proximity Read

Integrated systems biology identifies disruptions in mitochondrial function and metabolism as key contributors to heart failure with preserved ejection fraction (HFpEF)Semantic proximity Read

Reduced Myocardial Serine Synthesis Impairs Functional, Metabolic, and Redox Adaptations to Cardiac StressSemantic proximity Read

A Translational Model of MASLD-Associated HFpEF Defines Mitochondrial Dysfunction and Cardiac Plasticity During Disease Progression and RegressionSemantic proximity Read

Targeting Metabolic Dysfunction and Inflammation with Sotagliflozin Reverses Diastolic Dysfunction in Experimental HFpEFSemantic proximity Read

Humanin analogue promotes metabolic reprogramming to protect the ischemic heartSemantic proximity Read

Integrated left ventricular multi-omics landscape of human cardiometabolic HFpEF.Semantic proximity Read

Molecular Signature of HFpEFSemantic proximity Read

Mitochondrial Distress Signals at the Heart-Liver Interface: Molecular Links Between MASLD and Heart FailureSemantic proximity Read

Genetic Loss of Nicotinamide Nucleotide Transhydrogenase Prevents from Cardiometabolic Heart Failure with Preserved Ejection FractionSemantic proximity Read

Metabolic remodeling in hypertrophied and failing myocardium: a review.Semantic proximity Read

Cardiometabolic Phenotype in HFpEF: Insights from Murine ModelsSemantic proximity Read