Article

DELE1 promotes translation-associated homeostasis, growth, and survival in mitochondrial myopathy

2024-02-29

Abstract excerpt

Mitochondrial dysfunction causes devastating disorders, including mitochondrial myopathy. Here, we identified that diverse mitochondrial myopathy models elicit a protective mitochondrial integrated stress response (mt-ISR), mediated by OMA1-DELE1 signaling. The response was similar following disruptions in mtDNA maintenance, from knockout of Tfam , and mitochondrial protein unfolding, from disease-causing mutatio...

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Literature Corpus work: 55391c4b-d6f5-566e-8c14-2fd4c7ddc950
DOI: 10.1101/2024.02.29.582673

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