Article

Exercise based Intervention For Metabolic Inflexibility Linked With Lipid Storage Myopathy Using Innovative CRISPR <i>Etf-QO</i> Mutant Knock-in Models

2026-05-20

Abstract excerpt

Multiple acyl-CoA dehydrogenase deficiency (MADD) is a mitochondrial lipid storage myopathy characterized by impaired fatty acid β-oxidation, mitochondrial dysfunction, and progressive neuromuscular and cardiac disease. MADD is most commonly caused by pathogenic variants in electron transfer flavoprotein dehydrogenase (ETFDH), which encodes electron transfer flavoprotein–ubiquinone oxidoreductase (Etf-QO), a criti...

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Literature Corpus work: 9fc00855-9565-5d64-9e98-06d0ba9b0ee2
DOI: 10.64898/2026.05.18.726022

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