Article

Mitochondrial fatty acid synthesis is essential for coordinated energy transformation

2023-04-04

Abstract excerpt

Mitochondria warrant cellular energy demands by generating energy equivalents in central carbon metabolism. They are also able to newly synthesize fatty acids via mitochondrial fatty acid synthesis (mtFAS), however, the role of mtFAS for systemic metabolism has been poorly investigated. Here we show that mitochondrial Trans-2-Enoyl-CoA Reductase (MECR), a key enzyme of mtFAS, critically regulates cellular and syst...

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Literature Corpus work: d7567a18-6850-5d46-a971-ba5e0d532744
DOI: 10.1101/2023.04.03.23288010

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