Article
JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila.
The EMBO journal - 15 Nov 2006
Uhlirova Mirka, Bohmann Dirk
Abstract excerpt
Loss of the epithelial polarity gene scribble in clones of Drosophila imaginal disc cells can cooperate with Ras signaling to induce malignant tumors. Such mutant tissue overproliferates, resists apoptosis, leaves its place of origin and invades other organs, ultimately causing lethality. We show that increased Jun N-terminal kinase (JNK) signaling resulting from the loss of scribble promotes the movement of...
Topics
- Animals
- Apoptosis
- Cell Movement
- Cell Polarity
- Cell Proliferation
- Cell Survival
- Disease Models, Animal
- Drosophila
- Drosophila Proteins
- JNK Mitogen-Activated Protein Kinases
- Matrix Metalloproteinase 1