Article
Tumor suppression by cell competition through regulation of the Hippo pathway.
Proceedings of the National Academy of Sciences of the United States of America - 10 Jan 2012
Chen Chiao-Lin, Schroeder Molly C, Kango-Singh Madhuri, Tao Chunyao, Halder Georg
Abstract excerpt
Homeostatic mechanisms can eliminate abnormal cells to prevent diseases such as cancer. However, the underlying mechanisms of this surveillance are poorly understood. Here we investigated how clones of cells mutant for the neoplastic tumor suppressor gene scribble (scrib) are eliminated from Drosophila imaginal discs. When all cells in imaginal discs are mutant for scrib, they hyperactivate the Hippo pathway...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.