Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Towards delineating the chain of events that cause premature senescence in the accelerated aging syndrome Hutchinson-Gilford progeria (HGPS).

Biochemical Society transactions - 30 Jun 2020

Dreesen Oliver

Abstract excerpt

The metazoan nucleus is equipped with a meshwork of intermediate filament proteins called the A- and B-type lamins. Lamins lie beneath the inner nuclear membrane and serve as a nexus to maintain the architectural integrity of the nucleus, chromatin organization, DNA repair and replication and to regulate nucleocytoplasmic transport. Perturbations or mutations in various components of the nuclear lamina result in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging, Premature
Share to Cellular Senescence
Share to Cytoplasm

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Intermediate Filament Proteins

Share to Lamin Type A

Share to Nuclear Lamina

Share to Progeria

Share to Protein Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 32539085
DOI: 10.1042/BST20190882
PMCID: PMC7329345

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Towards delineating the chain of events that cause premature senescence in the accelerated aging syndrome Hutchinson-Gilford progeria (HGPS).PMID 32539085Read ↗

Molecular insights into the premature aging disease progeria.Semantic proximity Read ↗

Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations.Semantic proximity Read ↗

Premature aging syndromes: From patients to mechanism.Semantic proximity Read ↗

Unraveling the mysteries of aging through a Hutchinson-Gilford progeria syndrome model.Semantic proximity Read ↗

Hutchinson-Gilford Progeria Syndrome: An Overview of the Molecular Mechanism, Pathophysiology and Therapeutic Approach.Semantic proximity Read ↗

Hutchinson-Gilford progeria syndrome through the lens of transcription.Semantic proximity Read ↗

Epigenetic involvement in Hutchinson-Gilford progeria syndrome: a mini-review.Semantic proximity Read ↗

An overview of treatment strategies for Hutchinson-Gilford Progeria syndrome.Semantic proximity Read ↗

Genetics of aging, progeria and lamin disorders.Semantic proximity Read ↗

Hutchinson-Gilford progeria syndrome.Semantic proximity Read ↗

Hutchinson-Gilford Progeria Syndrome: A Premature Aging Disease.Semantic proximity Read ↗

Progerin, an Aberrant Spliced form of Lamin A, is a Potential Therapeutic Target for HGPSSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.