Molecular insights into the premature aging disease progeria.

doi:10.1007/s00418-016-1411-1

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Article

Molecular insights into the premature aging disease progeria.

Histochemistry and cell biology - 1 Apr 2016

Vidak Sandra, Foisner Roland

Abstract excerpt

Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare premature aging disease presenting many features resembling the normal aging process. HGPS patients die before the age of 20 years due to cardiovascular problems and heart failure. HGPS is linked to mutations in the LMNA gene encoding the intermediate filament protein lamin A. Lamin A is a major component of the nuclear lamina, a scaffold structure...

Topics

Aging, Premature
Cell Nucleus
Cellular Senescence
Humans
Lamin Type A
Mutation
Progeria

Source

Open in PubMed Open full text

Identifiers

PMID: 26847180
DOI: 10.1007/s00418-016-1411-1
PMCID: PMC4796323

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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