Article

Transcriptional profiling of Hutchinson-Gilford Progeria patients identifies primary target pathways of progerin

2025-09-20

Abstract excerpt

<h4>ABSTRACT</h4> Hutchinson Gilford Progeria Syndrome (HGPS) is an ultra-rare pediatric premature aging disorder. The disease is caused by a point mutation in the LMNA gene leading to the production of the dominant-negative progerin isoform of the nuclear envelope protein lamin A. Disease severity and progression amongst the population of ∼140 known patients is variable. Most of the mechanistic insights into th...

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Literature Corpus work: 5f397a27-c7b5-52d7-b97f-98fa7a7aa4b4
DOI: 10.1101/2025.09.18.677125

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