Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Association of progerin-interactive partner proteins with lamina proteins: Mel18 is associated with emerin in HGPS.

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences - 18 Aug 2009

Ju Wei-na, Brown W Ted, Zhong Nanbert

Abstract excerpt

OBJECTIVE: The Hutchinson-Gilford progeria syndrome (HGPS or progeria) is a childhood disorder with features of premature aging and is caused by mutations in the lamin A gene resulting in the production of an abnormal protein, termed progerin. To investigate the underlying pathogenic mechanism, we studied the nuclear co-localization and association of progerin interactive partner proteins (PIPPs) with lamina...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lamin Type A
Share to Membrane Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nuclear Lamina

Share to Nuclear Proteins

Share to Polycomb Repressive Complex 1

Share to Progeria

Share to Protein Precursors

Share to Repressor Proteins

Source

Identifiers

PMID: 19727227

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Association of progerin-interactive partner proteins with lamina proteins: Mel18 is associated with emerin in HGPS.PMID 19727227Read ↗

Towards delineating the chain of events that cause premature senescence in the accelerated aging syndrome Hutchinson-Gilford progeria (HGPS).Semantic proximity Read ↗

Molecular insights into the premature aging disease progeria.Semantic proximity Read ↗

Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations.Semantic proximity Read ↗

Identification of differential protein interactors of lamin A and progerin.Semantic proximity Read ↗

Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targeting.Semantic proximity Read ↗

Progerin, an Aberrant Spliced form of Lamin A, is a Potential Therapeutic Target for HGPSSemantic proximity Read ↗

Imbalanced Nucleocytoskeletal Connections Create Common Polarity Defects in Progeria and Physiological AgingSemantic proximity Read ↗

Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford Progeria SyndromeSemantic proximity Read ↗

The Anaphase Promoting Complex targets the toxic protein Progerin for ubiquitin-dependent degradation via autophagySemantic proximity Read ↗

Hutchinson-Gilford progeria syndrome.Semantic proximity Read ↗

Hutchinson-Gilford Progeria Syndrome: An Overview of the Molecular Mechanism, Pathophysiology and Therapeutic Approach.Semantic proximity Read ↗

Hutchinson-Gilford Progeria Syndrome—Current Status and Prospects for Gene Therapy TreatmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.