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Article

Hutchinson-Gilford Progeria Syndrome: A premature aging disease caused by LMNA gene mutations.

Ageing research reviews - 1 Jan 2017

Gonzalo Susana, Kreienkamp Ray, Askjaer Peter

Abstract excerpt

Products of the LMNA gene, primarily lamin A and C, are key components of the nuclear lamina, a proteinaceous meshwork that underlies the inner nuclear membrane and is essential for proper nuclear architecture. Alterations in lamin A and C that disrupt the integrity of the nuclear lamina affect a whole repertoire of nuclear functions, causing cellular decline. In humans, hundreds of mutations in the LMNA gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27374873
DOI: 10.1016/j.arr.2016.06.007
PMCID: PMC5195863

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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