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Progerin, an Aberrant Spliced form of Lamin A, is a Potential Therapeutic Target for HGPS

2023-08-10

Abstract excerpt

Hutchison-Gilford progeria syndrome (HGPS) is an extremely rare genetic disorder caused by the mutant protein progerin, which is expressed by the abnormal splicing of LMNA gene. HGPS affects systemic levels, except cognition or brain development in children, showing that cellular aging can occur in the short term. However, the causes of aging that humanity is working to overcome remain poorly understood. Studying...

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Literature Corpus work
e02dc20b-df90-589a-8761-ae06adf697e6
DOI
10.20944/preprints202308.0835.v1
Open publication

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