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Article

Structure of the nuclear exosome component Rrp6p reveals an interplay between the active site and the HRDC domain.

Proceedings of the National Academy of Sciences of the United States of America - 8 Aug 2006

Midtgaard Søren F, Assenholt Jannie, Jonstrup Anette Thyssen, Van Lan B, Jensen Torben Heick, Brodersen Ditlev E

Abstract excerpt

The multisubunit eukaryotic exosome is an essential RNA processing and degradation machine. In its nuclear form, the exosome associates with the auxiliary factor Rrp6p, which participates in both RNA processing and degradation reactions. The crystal structure of Saccharomyces cerevisiae Rrp6p displays a conserved RNase D core with a flanking HRDC (helicase and RNase D C-terminal) domain in an unusual conformation...

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Identifiers

PMID: 16882719
DOI: 10.1073/pnas.0604731103
PMCID: PMC2131688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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