Article

The human Dicer helicase domain mediates ATP hydrolysis and RNA rearrangement

2023-06-28

Abstract excerpt

Vertebrates have one Dicer ortholog that generates both microRNAs (miRNAs) and small interfering RNAs (siRNAs), in contrast to the multiple Dicer-like proteins found in flies and plants. Here, we focus on the functions of the human Dicer (hDicer) helicase domain. The helicase domain of hDicer is known to recognize pre-miRNA substrates through interactions with their apical loop regions. Besides interacting with ca...

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Literature Corpus work: 3b6dc389-42f3-555b-8f90-ce3afe29403a
DOI: 10.1101/2023.06.28.546842

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