Article

Deadenylation and Decapping Factors Cooperatively Stimulate Biochemical Activities of DEAD-Box ATPase Dhh1

2026-04-29

Abstract excerpt

<h4>ABSTRACT</h4> The DEAD-box ATPase Dhh1 (DDX6 in humans) is a general activator of 5’-3’ mRNA decay that acts between the deadenylation and decapping steps of the pathway, although the exact mechanism of its action remains unclear. Dhh1 has been shown to interact with the MIF4G domain of the central scaffold protein of the Ccr4-Not deadenylase complex, Not1, as well as the decapping activator Edc3. Although st...

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Literature Corpus work: 73ef887d-99e8-5b0f-a5a9-1c80aef6a89c
DOI: 10.64898/2026.04.28.721454

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