Article

Identification of human vaccinees that possess antibodies targeting the egg-adapted hemagglutinin receptor binding site of an H1N1 influenza vaccine strain

2018-01-17

Abstract excerpt

Human influenza viruses passaged in eggs often acquire mutations in the hemagglutinin (HA) receptor binding site (RBS). To determine if egg-adapted H1N1 vaccines commonly elicit antibodies targeting the egg-adapted RBS of HA, we completed hemagglutinin-inhibition assays with A/California/7/2009 HA and egg-adapted A/California/7/2009-X-179A HA using sera collected from 159 humans vaccinated with seasonal influenza...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 41725a5b-6be4-5276-8426-e30c912a0199
DOI: 10.1101/249615

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Identification of human vaccinees that possess antibodies targeting the egg-adapted hemagglutinin receptor binding site of an H1N1 influenza vaccine strainDOI 10.1101/249615Read

Identification of human vaccinees that possess antibodies targeting the egg-adapted hemagglutinin receptor binding site of an H1N1 influenza vaccine strainSemantic proximity Read

Egg-adaptive mutations in H3N2v vaccine virus enhance egg-based production without loss of antigenicity or immunogenicity.Semantic proximity Read

In-depth phylogenetic analysis of the hemagglutinin gene of influenza A(H3N2) viruses circulating during the 2016-2017 season revealed egg-adaptive mutations of vaccine strains.Semantic proximity Read

Redirecting antibody responses from egg-adapted epitopes following repeat vaccination with recombinant or cell culture-based versus egg-based influenza vaccinesSemantic proximity Read

Effects of egg-adaptation on receptor-binding and antigenic properties of recent influenza A (H3N2) vaccine virusesSemantic proximity Read

Differential Antibody Recognition of H3N2 Vaccine and Seasonal Influenza Virus Strains Based on Age, Vaccine Status, and Sex in the 2017-2018 Season.Semantic proximity Read

Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains.Semantic proximity Read

Egg-adaptive mutations of human influenza H3N2 virus are contingent on natural evolution.Semantic proximity Read

Molecular Characterisation of the Haemagglutinin Glycan-Binding Specificity of Egg-Adapted Vaccine Strains of the Pandemic 2009 H1N1 Swine Influenza A Virus.Semantic proximity Read

An egg-derived sulfated N-Acetyllactosamine glycan is an antigenic decoy of influenza virus vaccinesSemantic proximity Read

A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccineSemantic proximity Read

Influenza vaccines: the potential benefits of cell-culture isolation and manufacturingSemantic proximity Read