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Article

A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine

23 Oct 2017

Abstract excerpt

The effectiveness of the annual influenza vaccine has declined in recent years, especially for the H3N2 component, and is a concern for global public health. A major cause for this lack in effectiveness has been attributed to the egg-based vaccine production process. Substitutions on the hemagglutinin glycoprotein (HA) often arise during virus passaging that change its antigenicity and hence vaccine...

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PMID: 29059230
DOI: 10.1371/journal.ppat.1006682

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