Article

Upregulation of CYP1B1 by hypoxia is mediated by ERα activation in breast cancer cells

2022-02-04

Abstract excerpt

<title>Abstract</title> <p><bold>Background: </bold>Endocrine therapy for breast cancer often leads to drug resistance and tumor recurrence; tumor hypoxia is also associated with mortality and tumor relapse. Cytochrome P450 1B1 (CYP1B1) regulates estrogen metabolism in breast cells and is known to be overexpressed in breast cancer tissue. Although the individual association of hypoxia-induced hypoxia-inducible fa...

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Literature Corpus work: d8f90464-79d6-5ba7-87c5-08ef804a8683
DOI: 10.21203/rs.3.rs-1319305/v1

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