Article

An ERα-Dependent Hypoxia Response Defines EMT-Adjacent Tumour Regions and Suppresses the Pro-survival Effects of Amiloride in Estrogen Receptor-Positive Breast Cancer

2025-10-04

Abstract excerpt

Estrogen receptor-positive (ER+) breast cancer carries a lifelong risk of recurrence and disease progression, with hypoxia-associated transcriptional signatures linked to poor prognosis and therapy resistance. While the effects of hypoxia on tumour progression are well studied, the impact on ERα epigenomic regulation remains poorly characterised. Here, we demonstrate that activation of hypoxia-inducible factors (H...

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Literature Corpus work: 8b21c7ab-124b-56a6-aa61-3ec9081ce07d
DOI: 10.1101/2025.10.03.680339

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An ERα-Dependent Hypoxia Response Defines EMT-Adjacent Tumour Regions and Suppresses the Pro-survival Effects of Amiloride in Estrogen Receptor-Positive Breast CancerDOI 10.1101/2025.10.03.680339Read

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