Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancer

22 Jan 2019

Abstract excerpt

BACKGROUND: Tumour hypoxia is a driver of breast cancer progression associated with worse prognosis and more aggressive disease. The cellular response to hypoxia is mediated by the hypoxia-inducible transcription factors HIF-1 and HIF-2, whose transcriptional activity is canonically regulated through their oxygen-labile HIF-α subunits. These are constitutively degraded in the presence of oxygen; however, HIF-1α...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis and VEGF in Cancer
Share to Cancer Cells and Metastasis
Share to Cancer, Hypoxia, and Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30670058
DOI: 10.1186/s13058-019-1097-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HER2 regulates HIF-2α and drives an increased hypoxic response in breast cancerPMID 30670058Read ↗

Targeting Hypoxia and HIF1α in Triple-Negative Breast Cancer: New Insights from Gene Expression Profiling and Implications for TherapySemantic proximity Read ↗

Hypoxia-inducible factor in cancer: from pathway regulation to therapeutic opportunitySemantic proximity Read ↗

The transcriptional factors HIF-1 and HIF-2 and their novel inhibitors in cancer therapySemantic proximity Read ↗

HIFs, angiogenesis, and metabolism: elusive enemies in breast cancerSemantic proximity Read ↗

Hypoxia-inducible factors: central regulators of the tumor phenotype.Semantic proximity Read ↗

Hypoxia and ERα Transcriptional Crosstalk Is Associated with Endocrine Resistance in Breast CancerSemantic proximity Read ↗

Investigating hypoxia-inducible factor signaling in cancer: Mechanisms, clinical implications, targeted therapeutic strategies, and resistanceSemantic proximity Read ↗

Roles of Post-Translational Modifications of Transcription Factors Involved in Breast Cancer HypoxiaSemantic proximity Read ↗

Hypoxia-inducible factors: cancer progression and clinical translationSemantic proximity Read ↗

Hypoxia-mediated activation of hypoxia-inducible factor-1α in triple-negative breast cancer: A reviewSemantic proximity Read ↗

Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypesSemantic proximity Read ↗

ERBB2-Mediated Transcriptional Up-regulation of the α5β1 Integrin Fibronectin Receptor Promotes Tumor Cell Survival Under Adverse ConditionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.