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Article

Role of hypoxia-inducible factor-1α as a cancer therapy target

1 Dec 2006

Abstract excerpt

Hypoxia occurs in solid tumours due to a mismatch between tumour growth and angiogenesis. Hypoxia in solid tumours is associated with an aggressive phenotype and resistance to radiation therapy and chemotherapy leading to poor patient prognosis. Hypoxia-inducible factor-1 (HIF-1) is a transcription factor, which is activated in response to intratumoural hypoxia and as a result of genetic alterations that activate...

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PMID: 17259560
DOI: 10.1677/erc.1.01290

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