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Hypoxia-mediated activation of hypoxia-inducible factor-1α in triple-negative breast cancer: A review

27 Oct 2023

Abstract excerpt

Triple-negative breast cancer (TNBC) is a subtype of breast cancer (BC) that is highly aggressive and hypoxic compared with other subtypes. The role of hypoxia-inducible factor 1α (HIF-1α) as a key hypoxic transcription factor in oncogenic processes has been extensively studied. Recently, it has been shown that HIF-1α regulates the complex biological processes of TNBC, such as glycolysis, angiogenesis, invasion...

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PMID: 37904441
DOI: 10.1097/md.0000000000035493

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