Article
Hypoxia-inducible factor-1 in human breast and prostate cancer
1 Sept 2006
Abstract excerpt
The tumor microenvironment is best characterized as a fluctuation of hypoxia and nutrient deprivation, which leads to epigenetic and genetic adaptation of clones and increased invasiveness and metastasis. In turn, these hypoxic adaptations make the tumors more difficult to treat and confer increased resistance to current therapies. Part of this adaptation is the regulation of gene products in response to hypoxia....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.