Article

ERO1α as a potential drug target for breast cancer: a systematic review of current evidence

2025-08-29

Abstract excerpt

<h4>Aim: </h4> Recent studies reveal that hypoxia, oxidative stress, and impaired protein folding contribute to tumor development and breast cancer treatment resistance. Endoplasmic Reticulum Oxidoreductin 1 Alpha (ERO1α) regulates redox balance in the endoplasmic reticulum by reoxidizing protein disulfide isomerase, facilitating disulfide bond formation while generating reactive oxygen species. Elevated ERO1α lev...

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Literature Corpus work: 5c54e80d-4586-5b69-b3c7-e6237a26af6c
DOI: 10.22541/au.175648036.63225061/v1

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