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Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeleton

2025-10-20

Abstract excerpt

<title>Abstract</title> <p>Overexpression of complement genes in the tumor microenvironment, including Factor H (FH), is a strong predictor of poor prognosis in multiple cancers. Its canonical functions in the bloodborne complement cascade, though, cannot explain this prognostic impact. Here we demonstrate that FH operates within the intracellular space in fibroblasts and tumor cells. By transcriptomics approach...

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Literature Corpus work
d8f6696d-298d-5c76-8dc4-c5cc7e4f13d8
DOI
10.21203/rs.3.rs-5147456/v1
Open publication

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Intracellular complement Factor H promotes tumor progression through modulation of cell cycle and actin cytoskeletonDOI 10.21203/rs.3.rs-5147456/v1
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