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Article

The human complement factor H: functional roles, genetic variations and disease associations.

Molecular immunology - 1 Jun 2004

Rodríguez de Córdoba Santiago, Esparza-Gordillo Jorge, Goicoechea de Jorge Elena, Lopez-Trascasa Margarita, Sánchez-Corral Pilar

Abstract excerpt

Factor H is an essential regulatory protein that plays a critical role in the homeostasis of the complement system in plasma and in the protection of bystander host cells and tissues from damage by complement activation. Genetic and structural data generated during recent years have been instrumental to delineate the functional domains responsible for these regulatory activities in factor H, which is helping to...

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Identifiers

PMID: 15163532
DOI: 10.1016/j.molimm.2004.02.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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