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The complement system as a target in cancer immunotherapy

12 Jul 2024

Abstract excerpt

Malignant cells are part of a complex network within the tumor microenvironment, where their interaction with host cells and soluble mediators, including complement components, is pivotal. The complement system, known for its role in immune defense and homeostasis, exhibits a dual effect on cancer progression. This dichotomy arises from its antitumoral opsonophagocytosis and cytotoxicity versus its protumoral...

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PMID: 38996361
DOI: 10.1002/eji.202350820

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