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Article

Non-canonical extracellular complement pathways and the complosome paradigm in cancer: a scoping review

30 Apr 2025

Abstract excerpt

The Complement System (CS) comprises three catalytic pathways that can be activated by specific immune triggers. However, within the tumor microenvironment (TME), CS intracellular components, recently named as complosome, play roles that extend beyond the activation and regulation of its pathways. The interaction between TME elements and tumor cells alters the local immune response, leading to inflammation, cell...

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PMID: 40370471
DOI: 10.3389/fimmu.2025.1519465

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