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Functional Anatomy of Complement Factor H

23 May 2013

Abstract excerpt

Factor H (FH) is a soluble regulator of the proteolytic cascade at the core of the evolutionarily ancient vertebrate complement system. Although FH consists of a single chain of similar protein modules, it has a demanding job description. Its chief role is to prevent complement-mediated injury to healthy host cells and tissues. This entails recognition of molecular patterns on host surfaces combined with control...

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PMID: 23701234
DOI: 10.1021/bi4003452

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