Article

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predisposition

2023-03-10

Abstract excerpt

The human Red Hair Color (RHC) trait is caused by increased pheomelanin (red-yellow) and reduced eumelanin (black-brown) pigment in skin and hair due to diminished melanocortin 1 receptor (MC1R) function. In addition, individuals harboring the RHC trait are predisposed to melanoma development. While MC1R variants have been established as causative of RHC and are a well-defined risk factor for melanoma, it remains...

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Literature Corpus work: d8b73ab2-745e-5837-9a0a-964aa44dd5a3
DOI: 10.1101/2023.03.10.532018

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