Article

CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

2021-03-04

Abstract excerpt

Melanoma risk is 30 times higher in people with lightly pigmented skin compared to those with darkly pigmented skin. Here we show that this difference results from more than melanin pigment and its ultraviolet radiation (UVR) shielding effect. Using primary human melanocytes representing the full human skin pigment continuum and several preclinical melanoma models, we show that cell-intrinsic differences between d...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: eb2fb687-c227-5171-9fe0-1a893541aa11
DOI: 10.1101/2021.03.03.433757

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA ProductionDOI 10.1101/2021.03.03.433757Read

A genome-wide genetic screen uncovers novel determinants of human pigmentationSemantic proximity Read

Elucidation of Melanogenesis Cascade for Identifying Pathophysiology and Therapeutic Approach of Pigmentary Disorders and MelanomaSemantic proximity Read

A genome-wide genetic screen uncovers determinants of human pigmentationSemantic proximity Read

MC1R: Front and Center in the Bright Side of Dark Eumelanin and DNA RepairSemantic proximity Read

Metabolic Alterations and Therapeutic Opportunities in Rare Forms of Melanoma.Semantic proximity Read

Novel CRISPR-Cas9 BAP1 Knockout Pre-Clinical Tumor Model Recapitulates Human Melanoma Tumorigenesis and Immune EvolutionSemantic proximity Read

Loss of MC1R signaling implicates TBX3 in pheomelanogenesis and melanoma predispositionSemantic proximity Read

Intrinsic and extrinsic regulation of human skin melanogenesis and pigmentationSemantic proximity Read

Cellular mechanisms regulating human melanogenesisSemantic proximity Read

MC1R, the cAMP pathway, and the response to solar UV: extending the horizon beyond pigmentation.Semantic proximity Read

Dangerous liaisons: Loss of keratinocyte control over melanocytes in melanomagenesis.Semantic proximity Read