Article
Rare Germline Variants in CDKN2A-Negative Children and Adolescents With Cutaneous Melanoma.
Pigment cell & melanoma research - 1 Feb 2026
Johansson Peter A, Palmer Jane M, Bui-Raborn Linh T, Xu Mai, Jones Kristine M, Higson Herbert, Liu Jia, Brooks Kelly M, Pritchard Antonia L, Hayward Nicholas K, Brown Kevin M
Abstract excerpt
Cutaneous melanoma is a complex disease influenced by both environmental and genetic factors. Inherited susceptibility plays a significant role, involving a combination of high-, intermediate- and low-penetrance genes. Melanoma in children and adolescents has been speculated to have a stronger genetic component due to the early onset. This study investigates germline variants in early-onset melanoma through exome...
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