Article
Palmitoylation-dependent activation of MC1R prevents melanomagenesis.
Nature - 21 Sept 2017
Chen Shuyang, Zhu Bo, Yin Chengqian, Liu Wei, Han Changpeng, Chen Baoen, Liu Tongzheng, Li Xin, Chen Xiang, Li Chunying, Hu Limin, Zhou Jun, Xu Zhi-Xiang, Gao Xiumei, Wu Xu, Goding Colin R, Cui Rutao
Abstract excerpt
The melanocortin-1 receptor (MC1R), a G-protein-coupled receptor, has a crucial role in human and mouse pigmentation. Activation of MC1R in melanocytes by α-melanocyte-stimulating hormone (α-MSH) stimulates cAMP signalling and melanin production and enhances DNA repair after ultraviolet irradiation. Individuals carrying MC1R variants, especially those associated with red hair colour, fair skin and poor tanning...
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