Article
Genomic expression differences between cutaneous cells from red hair color individuals and black hair color individuals based on bioinformatic analysis.
Oncotarget - 14 Feb 2017
Puig-Butille Joan Anton, Gimenez-Xavier Pol, Visconti Alessia, Nsengimana Jérémie, Garcia-García Francisco, Tell-Marti Gemma, Escamez Maria José, Newton-Bishop Julia, Bataille Veronique, Del Río Marcela, Dopazo Joaquín, Falchi Mario, Puig Susana
Abstract excerpt
The MC1R gene plays a crucial role in pigmentation synthesis. Loss-of-function MC1R variants, which impair protein function, are associated with red hair color (RHC) phenotype and increased skin cancer risk. Cultured cutaneous cells bearing loss-of-function MC1R variants show a distinct gene expression profile compared to wild-type MC1R cultured cutaneous cells. We analysed the gene signature associated with RHC...
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