Article
A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease.
Nature communications - 4 Nov 2019
Sun Qi, Lee Wendy, Mohri Yasuaki, Takeo Makoto, Lim Chae Ho, Xu Xiaowei, Myung Peggy, Atit Radhika P, Taketo M Mark, Moubarak Rana S, Schober Markus, Osman Iman, Gay Denise L, Saur Dieter, Nishimura Emi K, Ito Mayumi
Abstract excerpt
Melanoma, the deadliest skin cancer, remains largely incurable at advanced stages. Currently, there is a lack of animal models that resemble human melanoma initiation and progression. Recent studies using a Tyr-CreER driven mouse model have drawn contradictory conclusions about the potential of melanocyte stem cells (McSCs) to form melanoma. Here, we employ a c-Kit-CreER-driven model that specifically targets...
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