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A genome-wide genetic screen uncovers novel determinants of human pigmentation

2021-10-01

Abstract excerpt

The skin color is one of the most diverse human traits and is determined by the quantity, type and distribution of melanin. Here, we leverage light scattering properties of melanin to conduct a genome-wide CRISPR-Cas9 screen for novel regulators of melanogenesis. We identify functionally diverse genes converging on melanosome biogenesis, endosomal transport and transcriptional/posttranscriptional gene regulation,...

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Literature Corpus work
36a21ca5-0b3d-5206-a23d-b31a600d32f4
DOI
10.1101/2021.09.29.462413
Open publication

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A genome-wide genetic screen uncovers novel determinants of human pigmentationDOI 10.1101/2021.09.29.462413
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