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A genome-wide genetic screen uncovers determinants of human pigmentation

10 Aug 2023

Abstract excerpt

Skin color, one of the most diverse human traits, is determined by the quantity, type, and distribution of melanin. In this study, we leveraged the light-scattering properties of melanin to conduct a genome-wide screen for regulators of melanogenesis. We identified 169 functionally diverse genes that converge on melanosome biogenesis, endosomal transport, and gene regulation, of which 135 represented previously...

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PMID: 37561850
DOI: 10.1126/science.ade6289

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