Assessing the Molecular Validity of Spontaneous Lupus Mouse Models and Its Implication for Human Studies

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by a loss of self-tolerance, causing inflammation and tissue damage in multiple organs. Animal models have advanced our understanding of SLE’s molecular basis, but the FDA’s recent elimination of animal testing requirements for drug approval has raised concerns about their validity, prompting a...

Topics

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• Cytokine Signaling Pathways and Interactions
• Disease Models, Animal
• Genetic Linkage
• Genetic Predisposition to Disease
• Lupus Erythematosus, Systemic
• Mice
• Systemic Lupus Erythematosus Research
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

d88e7475-10da-5a7a-ac27-886a4e2e9cfa

DOI

10.1101/2025.05.15.654304