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Article

Single cell RNA sequencing reveals ferritin as a key mediator of autoimmune pre-disposition in a mouse model of systemic lupus erythematosus.

Scientific reports - 20 Dec 2021

Younes Subhi Talal, Showmaker Kurt, Johnson Ashley C, Garrett Michael R, Ryan Michael J

Abstract excerpt

Systemic lupus erythematosus (SLE) is a devastating autoimmune disorder characterized by failure of self-tolerance with resultant production of autoreactive antibodies. The etiology of this syndrome is complex, involving perturbations in immune cell signaling and development. The NZBWF1 mouse spontaneously develops a lupus-like syndrome and has been widely used as a model of SLE for over 60 years. The NZBWF1...

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Identifiers

PMID: 34930978
DOI: 10.1038/s41598-021-03649-2
PMCID: PMC8688484

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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