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Article

New insights into disease pathogenesis from mouse lupus genetics.

Current opinion in immunology - 1 Dec 2004

Jørgensen Trine N, Gubbels Melanie R, Kotzin Brian L

Abstract excerpt

Full manifestation of mouse lupus, similar to the human disease in its severe form, is characterized by elevated antinuclear autoantibody levels and the development of kidney disease. Considerable evidence supports a genetic basis for lupus. The functional dissection of susceptibility loci in multigenic mouse models of lupus has provided insight into the immune abnormalities associated with autoantibody...

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Identifiers

PMID: 15511674
DOI: 10.1016/j.coi.2004.09.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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