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Article

Cross-species transcriptome analysis for early detection and specific therapeutic targeting of human lupus nephritis

29 Jul 2022

Abstract excerpt

OBJECTIVES: Patients with lupus nephritis (LN) are in urgent need for early diagnosis and therapeutic interventions targeting aberrant molecular pathways enriched in affected kidneys. METHODS: We used mRNA-sequencing in effector (spleen) and target (kidneys, brain) tissues from lupus and control mice at sequential time points, and in the blood from 367 individuals (261 systemic lupus erythematosus (SLE) patients...

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PMID: 35906002
DOI: 10.1136/annrheumdis-2021-222069

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