Article

Silencing of transposable elements may not be a major driver of regulatory evolution in primate induced pluripotent stem cells

2017-05-28

Abstract excerpt

Transposable elements (TEs) comprise a substantial proportion of primate genomes. The regulatory potential of TEs can result in deleterious effects, especially during development. It has been suggested that, in pluripotent stem cells, TEs are targeted for silencing by KRAB-ZNF proteins, which recruit the TRIM28-SETDB1 complex, to deposit the repressive histone modification H3K9me3. TEs, in turn, can acquire mutati...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bab6088c-23b3-5b7e-83eb-d17fe2b44030
DOI: 10.1101/142455

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Silencing of transposable elements may not be a major driver of regulatory evolution in primate induced pluripotent stem cellsDOI 10.1101/142455Read

Regulatory Transposable Elements in the Encyclopedia of DNA ElementsSemantic proximity Read

MER57E3 transposable element subfamily co-opted for gene regulation in human early neural developmentSemantic proximity Read

The impact of transposable elements on mammalian development.Semantic proximity Read

Tissue-specific restriction of TE-derived regulatory elements safeguards cell-type identitySemantic proximity Read

Transposable elements generate regulatory novelty in a tissue-specific fashionSemantic proximity Read

Transposable elements drive species-specific and tissue-specific transcriptomes in human developmentSemantic proximity Read

Genome-wide maps of chromatin state in pluripotent and lineage-committed cells.Semantic proximity Read

Transposable elements: an abundant and natural source of regulatory sequences for host genes.Semantic proximity Read

What Doesn't Kill You Makes You Stronger: Transposons as Dual Players in Chromatin Regulation and Genomic Variation.Semantic proximity Read

The KZFP/KAP1 system controls transposable elements-embedded regulatory sequences in adult T cellsSemantic proximity Read

Transposable elements and their KZFP controllers are drivers of transcriptional innovation in the developing human brainSemantic proximity Read

Regulatory networks of KRAB zinc finger genes and transposable elements changed during human brain evolution and diseaseSemantic proximity Read