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Article

The role of KRAB zinc-finger proteins in expanding the domestication potential of transposable elements.

Nature genetics - 1 Mar 2026

Davis Juliette, Voicu Diana, Chitnavis Urvashi, Jaksina Jeremi, Imbeault Michael

Abstract excerpt

KRAB zinc-finger proteins (KZFPs) are the most abundant family of DNA-binding proteins in humans and primarily induce the epigenetic silencing of transposable elements. While KZFPs use this ability to control the transposition potential of transposable elements, they can also act as epigenetic switches that gate transposable element-derived cis-regulatory modules in a cell context-specific manner. In this way,...

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Identifiers

PMID: 41720928
DOI: 10.1038/s41588-025-02498-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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