Article

Non-essential function of KRAB zinc finger gene clusters in retrotransposon suppression

2020-01-17

Abstract excerpt

The Krüppel-associated box zinc finger protein (KRAB-ZFP) family amplified and diversified in mammals by segmental duplications, but the function of the majority of this gene family remains largely unexplored due to the inaccessibility of the gene clusters to conventional gene targeting. We determined the genomic binding sites of 61 murine KRAB-ZFPs and genetically deleted in mouse embryonic stem (ES) cells five l...

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Literature Corpus work: 7c05d713-cbea-5c8c-8acb-d293083a1057
DOI: 10.1101/2020.01.17.910679

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