Article
KRAB-zinc finger protein gene expansion in response to active retrotransposons in the murine lineage.
eLife - 1 Jun 2020
Wolf Gernot, de Iaco Alberto, Sun Ming-An, Bruno Melania, Tinkham Matthew, Hoang Don, Mitra Apratim, Ralls Sherry, Trono Didier, Macfarlan Todd S
Abstract excerpt
The Krüppel-associated box zinc finger protein (KRAB-ZFP) family diversified in mammals. The majority of human KRAB-ZFPs bind transposable elements (TEs), however, since most TEs are inactive in humans it is unclear whether KRAB-ZFPs emerged to suppress TEs. We demonstrate that many recently emerged murine KRAB-ZFPs also bind to TEs, including the active ETn, IAP, and L1 families. Using a CRISPR/Cas9-based...
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