Article

Transposable elements and their KZFP controllers are drivers of transcriptional innovation in the developing human brain

2020-12-14

Abstract excerpt

Transposable elements (TEs) constitute 50% of the human genome and many have been co-opted throughout human evolution due to gain of advantageous regulatory functions controlling gene expression networks. Several lines of evidence suggest these networks can be fine-tuned by the largest family of TE controllers, the KRAB-containing zinc finger proteins (KZFPs). One tissue permissive for TE transcriptional activatio...

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Literature Corpus work: e1b4da16-08bc-5520-b7f5-f9d6fae37032
DOI: 10.1101/2020.12.14.422620

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